PGC-1α, a New Therapeutic Target in Huntington's Disease?
نویسندگان
چکیده
The coactivator PGC-1α is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1α expression is downregulated in patients with Huntington’s disease (HD) and in several animal models of this neurodegenerative disorder, implicating PGC-1α in HD pathogenesis and providing a connection between impaired energy metabolism and neurodegeneration (Cui et al., 2006; Weydt et al., 2006; St-Pierre et al., 2006).
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ورودعنوان ژورنال:
- Cell
دوره 127 شماره
صفحات -
تاریخ انتشار 2006